Extended Data Fig. 2: CRTC-1CBD drives a transcriptional shift in H3K4me3-deficient animals.
From: The CRTC-1 transcriptional domain is required for COMPASS complex-mediated longevity in C. elegans
a, GC-MS quantification of fatty acids. Mean ± SEM, from three biological replicates, P values by unpaired two-way ANOVA. b, Principal component analysis of the RNA-Seq data showing similarity between samples. Regularized log (rlog) transformed count was used, and principal components one and two were plotted on the x and y axes, respectively. c, Over-representation analysis of the Gene Ontology biological process terms for genes comprising all comparisons from the RNA-Seq samples: wild-type, set-2, crtc-1CBD−/−, and crtc-1CBD−/−;set-2 strains. The q-value cut-off is set as 0.05, with other parameters set as default.
