Extended Data Fig. 8: Rejuvenation in middle-aged 4F-Non Liv/Int mice upon in vivo reprogramming.
From: In vivo reprogramming leads to premature death linked to hepatic and intestinal failure
a, Experimental design indicating doxycycline administration protocol, activity measure by open field (OF) test, and organ and blood collection. b, Survival of 4F-Flox after 4 days of administration of doxycycline and middle-aged 4F Non-Liver/Intestine mice after 2 cycles of 10 days of doxycycline administration. c, mRNA levels of Oct4 and d, Epigenetic clock analysis in control and middle-aged 4F Non-Liver/Intestine mice after 2 cycles of 10 days of doxycycline administration. Data show mean ± SEM. Statistical significance was assessed by (c, d) two-sided unpaired t-test and Mann-Whiney - Wilcoxon test and b, log-rank (Mantel-Cox) test.
