Extended Data Fig. 2: Instestinal analysis after in vivo reprogramming.
From: In vivo reprogramming leads to premature death linked to hepatic and intestinal failure
a, Small intestine hematoxylin and eosin staining for an untreated controls and 4Fj mice and treated 4Fj and 4Fs-B mice during 4 days; white arrowhead points apoptotic figures, black arrowhead points an example of globet cell, black arrows points dedifferentiated enterocytes. b, Alpha diversity of the microbiota at the AVS level of the 3 groups at each time point. The table inside the Chao1 plot represents the number of mice samples per group at each time point. c, Results of the Bonferroni-corrected pairwise Wilcoxon test of the Chao1 (bottom diagonal matrix) and Shannon (upper diagonal matrix) indexes. P-values intervals: *** (0, 0.001], ** (0.001, 0.01], * (0.01, 0.05], * (0.05, 0.1]. d, Distance-based redundacy analysis by Bray-Curtis distance. Variance explained by the model: 0.453. Axis1 and 2 explain 0.689 and 0.180 of the model variance, respectively. Arrows show the effect and direction of the explanatory variables. Samples are represented by dots and their colour indicates their group plus time point. Diamonds represents differentially abundant genera identified by NBZIMM with the same formula as the dbRDA model.
