Fig. 3: Replication of AD subtypes in six cohorts.

a, Subtype probability for each individual in six replication cohorts. Most individuals showed high probability for one subtype only. b–e, Subtype comparisons on CSF t-tau levels (b), p-tau (c), age (d) and the CSF over serum albumin ratio (e) for each replication cohort when available. b–e, The boxplots depict the median in the center, the boundaries indicate the first and third quartiles, the whiskers extend up and down to 1.5 times the interquartile range (limited to actual observed data points) and the points indicate individual person values. The number of individuals per group in the boxplots are listed in Supplementary Tables 12 and 13, and provides the statistical metrics for the comparisons. NA, not applicable.