Extended Data Fig. 1: Trajectories of repeated cognitive test scores over time for AD subtypes.

Analyses were stratified according to clinical stage. In all plots the grey line represents the trajectory of the control group (that is, individuals with intact cognition and normal CSF markers). * indicates that the slope differs from zero with p < 0.05. a indicates slope different from controls, b indicates slope different from subtype 1, c indicates slope different from subtype 2, d indicates slope different from subtype 3, e indicates slope different from subtype 4 and f indicates slope different from subtype 5. See Supplementary Table 7 for statistical metrics.