Extended Data Fig. 4: Comparing Alzheimer’s disease (AD) subtypes on protein levels against controls, plotted separately according to clinical stage.

Left for cognitively normal with abnormal amyloid, middle for MCI with abnormal amyloid and right for AD dementia and abnormal amyloid. Plots indicates highly similar subtype patterns, suggesting that protein levels reflect particular AD related traits. See Supplementary Table 5 columns CY to HU for statistical metrics of subtype comparisons within each clinical stage. All proteins were scaled according to the mean and standard deviation of the control group, such that positive values indicate higher levels than controls, and negative values lower levels than controls.