Extended Data Fig. 3: Relationship between estimated causal effects and evolutionary conservation.
From: Causality-enriched epigenetic age uncouples damage and adaptation
Box plot shows the distribution of conservation scores in causal and non-causal CpG sites. Conservation scores were obtained by Learning Evidence of Conservation from Integrated Functional genomic annotations (LECIF), phastCons, and phyloP. Scatter plot shows the relationship between the absolute adjusted effect size and conservation score. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001. From left to right, the exact P-value for the top three panels are 1.23e-0, 0.00392, 0.00213.
