Extended Data Fig. 3: Cellular and humoral immune responses stratified by serostatus for CMV. | Nature Aging

Extended Data Fig. 3: Cellular and humoral immune responses stratified by serostatus for CMV.

From: Age differentially impacts adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19

Extended Data Fig. 3

(a) Serostatus for CMV by age (groups Y, M, and O). (b) Absolute numbers of naive (N, CD27+CD45RA+), central memory (CM, CD27+CD45RA−), effector memory (EM, CD27−CD45RA−), and terminally differentiated effector memory T cells (EMRA, CD27−CD45RA+), naive (CD27−CD38+) and memory B cells (CD27+CD38–), and plasmablasts (CD27+CD38+) in donors aged 18–49 years stratified as seronegative (n = 61) or seropositive for CMV (n = 72). Data are shown as radar plots representing mean values. (c) Anti-RBD IgG titers after primary vaccination in donors aged 18–49 years stratified as seronegative (ChAdOx1-S, n = 14; BNT162b2, n = 45) or seropositive for CMV (ChAdOx1-S, n = 30; BNT162b2, n = 36). (d) Spike-specific CD8+ T cell frequencies measured via the recall induction of IFNγ or TNF after transient expansion from donors aged <50 years stratified as seronegative (ChAdOx1-S, n = 9; BNT162b2, n = 23) or seropositive for CMV (ChAdOx1-S, n = 21; BNT162b2, n = 16). Horizontal lines represent median values (c, d). ***P < 0.001 (CMV− versus CMV+, two-sided Mann–Whitney U test with Bonferroni correction).

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