Extended Data Fig. 5: MCU is not required for HSC maintenance under homeostatic condition at young age.
From: An NAD+-dependent metabolic checkpoint regulates hematopoietic stem cell activation and aging
a-d. Comparison of 7-month-old WT and MCU KO mice. A. HSC number in the bone marrow analyzed via flow cytometry (p = 0.2488). n = 6. B. 7-AAD staining of HSCs analyzed via flow cytometry (p = 0.2157). n = 6. C. Lineage differentiation in the peripheral blood analyzed via flow cytometry. MNCs, mononuclear cells (p = 0.2453). n = 10 and 11. D. Bone marrow cellularity normalized by body weight (p = 0.1160). n = 6. Data are presented as mean values +/- SE. ns: p > 0.05. One-sided student’s t test.
