Extended Data Fig. 6: Age enhances purifying selection on the mouse m.12918 G > A mutation during maternal transmission.
(a) Mutation loads in pups born to individual females of varying ages. Data are median ± 95% CI. This dataset correspond to those in Fig. 6e, with in-depth individual details. Female mutation loads are displayed along the x-axis. (b) Mutation load in M2 oocytes from individual females of varying ages. Data are median ± 95% CI. This dataset correspond to those in Fig. 6g, with in-depth individual details. Female mutation loads are displayed along the x-axis. (c) Normalized mutation loads throughout oocyte development and in pups from multiple females at 22-week-old. Data are median ± 95% CI; with p-value from Kruskal-Wallis test followed by Dunn’s multiple comparisons. (d) Normalized mutation loads at different oocyte development and M2 from young females under 4 weeks old. Data are median ± 95% CI; with p-value from one-way ANOVA followed by Tukey’s multiple comparisons.
