Extended Data Fig. 7: Spatial transcriptomic analysis of the ovary. | Nature Aging

Extended Data Fig. 7: Spatial transcriptomic analysis of the ovary.

From: Maternal age enhances purifying selection on pathogenic mutations in complex I genes of mammalian mtDNA

Extended Data Fig. 7

(a) Top row: H&E staining of ovarian sections from ND1 mutant and WT mice. Bottom row: Gdf9 gene expression profile obtained from spatial transcriptomics on adjacent sections for Stero-seq. Arrows indicate oocytes in secondary follicles (#1-10); while arrowheads point to oocytes in other follicles (#11, #12, #13, #16, #17), follicle-free regions (#15) or no mached follicle region (#14) in top H&E image (for detail in Supplementary Table 3). (b) Schematic diagram of the spatial transcriptomics analysis workflow applied in this study, detailing the step-by-step process from initial tissue sectioning to the final analysis and data interpretation.

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