Extended Data Fig. 1: Flowchart of participants included in the main analysis.
From: Gut microbial features and circulating metabolomic signatures of frailty in older adults

The diagram illustrates the sample selection process. First, participants with missing complete frailty or age information were excluded. The remaining participants were further selected based on the availability of metagenomic (n = 1,448) and metabolomic profiles (n = 1,771), resulting in a final sample of 1,415 participants for integrated analysis.