Extended Data Fig. 4: Dementia risk in the Atherosclerosis Risk in Communities (ARIC) study.

A forest plot shows odds ratio of pre-existing all-cause dementia associated with candidate proteins. Adjusted odds of dementia risk were derived from binary logistic regression models (n = 4,743) adjusted for age, sex, race-center, education, APOEε4, eGFR-creatinine, and cardiovascular risk factors (BMI, diabetes, hypertension, and current smoking status). Pink circles reflect statistically significant associations. Data are presented as odds ratios and 95% confidence intervals. Statistical significance was defined at two-sided p < 0.05 without adjustment for multiple comparisons. The exact p-values are presented in the source data files, Supplementary Table 22.