Extended Data Fig. 1: Annual changes in lobar white and gray matter volumes associated with infections. | Nature Aging

Extended Data Fig. 1: Annual changes in lobar white and gray matter volumes associated with infections.

From: Proteomics identifies potential immunological drivers of postinfection brain atrophy and cognitive decline

Extended Data Fig. 1

Forest plots show the associations of brain volume loss over time with a influenza b human herpes viruses c miscellaneous viral infections d upper respiratory tract infections e lower respiratory tract infections and F skin/subcutaneous infections in the Baltimore Longitudinal Study of Aging. Data are presented as beta coefficients and 95% confidence intervals. Pink squares reflect statistically significant associations. Adjusted differences in annual changes of standardized brain volumes associated with history of a given infection (β) were derived from linear mixed-effects models (n = 982) adjusted for intracranial volume, baseline age, sex, race, education, APOEε4, a comorbidity index (that is, obesity, hypertension, diabetes, cancer, ischemic heart disease, chronic heart failure, chronic kidney disease, and chronic obstructive pulmonary disease), and two-way interactions of covariates with time. Statistical significance was defined at two-sided p < 0.05 without adjustment for multiple comparisons. The exact p-values are presented in the source data files, Supplementary Table 4.

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