Extended Data Fig. 2: 753b has no effect on the levels of Cdkn2a expression in the lung, kidney and fat tissues but reduces hepatic expression of SASP factors in naturally aged mice.
A. The levels of Cdkn2a mRNA in the lung, kidney and inguinal fat from untreated young mice and naturally aged mice treated with VEH and 753b. B. The levels of Cxcl12, Ccl5, Ccl2, Cxcl10, Mmp3, Mmp13, Il6, Il1a, Tnfa, and Tnfsf11 in the liver tissue from untreated young mice and naturally aged mice treated with VEH and 753b. The data are presented as means ± SEM (n = 7, 6, and 7 mice per group for young mice, VEH- and 753b-treated aged mice, respectively) and were analyzed by one-way ANOVAs with Å Ãdák’s multiple comparisons test or Tukey’s multiple comparisons test.
