Extended Data Fig. 3: 753b reduces splenic expression of SASP factors in naturally aged mice. | Nature Aging

Extended Data Fig. 3: 753b reduces splenic expression of SASP factors in naturally aged mice.

From: A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice

Extended Data Fig. 3

The levels of Il1b, Serpine1, Mmp3, Mmp13, Cxcl12, Ccl5, Ccl2, Cxcl10, Il6, Il1a, Tnfa, and Tnfsf11 in the spleens from untreated young mice and naturally aged mice treated with VEH and 753b. The data are presented as means ± SEM (n = 8, 6, and 7 mice per group for young mice, VEH- and 753b-treated aged mice, respectively) and were analyzed by one-way ANOVAs with Šídák’s multiple comparisons test or Tukey’s multiple comparisons test.

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