Fig. 1: Aging and rejuvenation of planarian eyes.
From: Regeneration leads to global tissue rejuvenation in aging sexual planarians
a, Morphological changes in the eyes of S. mediterranea and S. polychroa, from left to right. Cyan arrowheads indicate ectopic eyes, ectopic eye pigment cells and duplicated eyes (EEP). Scale bars, 0.5 mm. b, The ratio of worms with EEP phenotypes as a function of age. Each data point represents an independent container of worms with n ≥ 4 individuals and 744 individuals were sampled. Two-sided standard two-sample t-test. MO, months. c, Whole-body size changes with age in worms with and without EEP. Each data point represents an individual animal. n ≥ 12 for each age condition and a total of 200 individuals were included. Two-sided Welch’s t-test. In the box plots (b and c), the center is the median, the height of the box is given by the interquartile range (IQR), the whiskers extend up to 1.5 times the IQR, and the minima and maxima are the observed minima and maxima. d, Whole-head regeneration (top, n = 15) and half-head regeneration (bottom, n = 10) of worms with EEP. e, Regeneration of a half head with EEP into a new worm (n = 5). Dashed line indicates the amputation plane. Cyan arrowheads indicate old eyes; red arrowheads indicate new eyes. Scale bar, 0.5 mm.
