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X inactivation

X inactivation shows frail ends when mice age

Nature Aging volume 5, pages 962–963 (2025)Cite this article

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Most genes on the inactive X chromosome are repressed throughout life, but there are exceptions. Hoelzl and colleagues map genes that escape repression in multiple organs over the lifespan of mice and show an increased rate of escape during aging, as well as association with human disease.

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Fig. 1: Escape from X chromosome inactivation over the lifespan of mice.

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Authors and Affiliations

  1. Institute of Molecular Health Sciences, Department of Biology, Swiss Federal Institute of Technology ETH Hoenggerberg, Zurich, Switzerland

    Anton Wutz

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  1. Anton Wutz
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Correspondence to Anton Wutz.

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The author declares no competing interests.

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Wutz, A. X inactivation shows frail ends when mice age. Nat Aging 5, 962–963 (2025). https://doi.org/10.1038/s43587-025-00874-6

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