Fig. 2: Trametinib alone extends lifespan and acts additively with rapamycin to do so.
a, Schematic overview of trametinib and rapamycin treatment. b,c, Survival of female (b) and male (c) mice. Trametinib significantly increased survival in both sexes. Combined treatment significantly increased lifespan compared to the individual drug treatments (log-rank test). Curves represent pooled survival data from the lifespan, tissue collection and phenotyping cohorts (sample size: control ♂ n = 121, ♀ n = 100; rapamycin ♂ n = 120, ♀ n = 98, trametinib ♂ n = 121, ♀ n = 98; combined ♂ n = 120, ♀ n = 98). For survival data of the individual cohorts, see Extended Data Fig. 2a–f. Lifespan studies of control and drug-treated animals were performed at the same time within the cohorts. M, months.
