Extended Data Fig. 10: Distinct cell types identified by snRNAseq from 9-month-old wildtype and 5xFAD cortex and hippocampus with and without expression of ACE in microglia. | Nature Aging

Extended Data Fig. 10: Distinct cell types identified by snRNAseq from 9-month-old wildtype and 5xFAD cortex and hippocampus with and without expression of ACE in microglia.

From: Boosting angiotensin-converting enzyme (ACE) in microglia protects against Alzheimer’s disease in 5xFAD mice

Extended Data Fig. 10

a, UMAP principal component analysis of 10 clusters and the relative percent of nuclei within each cluster from SN1-SN8 (cluster number shown in parentheses). b, Cell lineage restricted gene expression defines cluster cellular identity. c, C1qa, Hexb and P2ry12, genes expressed relatively specifically in microglia, map to clusters annotated as microglia (all cell nuclei shown in grey).

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