Extended Data Fig. 1: Axis structure of cytokines run with PCA rather than FA.

Biplots show the associations of cytokines with the first two axes run in different datasets and with different sets of cytokines. The colors of each arrow are reproduced from panel A across panels to facilitate comparison, with red indicating strong association with the first factor in panel A, purple with the second factor, and black with the origin (no association). A color pattern similar to panel A thus indicates a similar axis structure. The first column (panels A, B, E, and H) shows analyses run in InCHIANTI, but with subsets of cytokines that overlap with those available, respectively, in the full InCHIANTI set (A), SLAS (B), THLHP (E), and OA HeLP (H). The second column (panels C, F, and I) shows the axis structure of the same cytokines as in column 1 (panels B, E, and H, respectively), except run in the target datasets, not InCHIANTI. The third column (panels D, G, and J) replicates the analysis in the second column but adding in the cytokines not measured in InCHIANTI (light grey).