Fig. 8: Systemic supplementation of CoQ10 can enhance quadriceps quality in OA joints of mice and mitigate cartilage damage. | Nature Aging

Fig. 8: Systemic supplementation of CoQ10 can enhance quadriceps quality in OA joints of mice and mitigate cartilage damage.

From: Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy

Fig. 8

a, Illustration of mitochondrial metabolic transformation pathway of CoQ10 and its role in the suppression of ferroptosis. b, Scheme of CoQ10 intervention in DMM-induced OA mice. c–e, Representative TEM images (c), mitochondrial area distribution (d) and mean mitochondrial area (e) of quadriceps from mice with or without CoQ10 intervention (n = 6 sham, n = 12 DMM+vehicle, n = 11 DMM+CoQ10). f,g, The quantification of LPO (n = 6 sham, n = 5 DMM+vehicle, n = 6 DMM+CoQ10) (f) and the distribution and mean CSA analysis of the total, MyHC-IIa and MyHC-IIb myofibers (n = 5 sham, n = 5 DMM+vehicle, n = 6 DMM+CoQ10) (g) in quadriceps of mice with or without CoQ10 intervention. h, Representative Safranine O/Fast Green staining images along OARSI scores of joint cartilage in mice with or without CoQ10 supplementation (n = 11 sham, n = 14 DMM+vehicle, n = 15 DMM+CoQ10). Student’s t-test (g (ratio of IIa to IIb)). Data are presented as mean ± s.e.m. unless otherwise noted; all statistical tests were two-sided unless otherwise noted; and n represents biological replicates unless otherwise noted. One-way ANOVA with Bonferroni test (f). Two-way ANOVA with Bonferroni test (d,g (distribution of CSA)). Kruskal–Wallis test (e,h). Median (25% IQR, 75% IQR; e,h).

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