Extended Data Fig. 10: Changes related to brain aging in EVsABPCs-treated aged rhesus macaques.
a, A quantitative analysis was performed to evaluate changes in cortical thickness and surface area following EVs treatment (n = 3). b, VBM analysis showed region variations in GMV among groups, with red areas indicating significant differences in GMV. Quantitative analysis of the significantly different brain regions in GMV following different treatments (n = 3). c, The comparison of GMV between pre-treatment and post-treatment at an uncorrected P-value threshold was performed specifically for the EVsABPCs group. Quantification of GMV changes between pre-treatment and post-treatment in the EVsABPCs group was conducted without correction for multiple comparisons (n = 3). The lines connect the same individuals, showing the trend between pre- and post-treatment. d, A quantitative analysis of the changes of FA and RD following EVs treatment (n = 3). Statistical analyses were performed using the Kruskal–Wallis nonparametric test followed by post hoc pairwise comparisons followed by one-tailed Mann–Whitney U-tests with FWE correction (a and d), or not (b); one-tailed Wilcoxon matched-pairs signed rank test for within-group comparisons (c). Data were presented as mean ± s.d. Uncorrected *P < 0.05.
