Extended Data Fig. 4: Cluster 5 represents bona fide nerve-associated macrophages in adipose tissue. | Nature Aging

Extended Data Fig. 4: Cluster 5 represents bona fide nerve-associated macrophages in adipose tissue.

From: Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation

Extended Data Fig. 4: Cluster 5 represents bona fide nerve-associated macrophages in adipose tissue.

(a) Violin plot depicting the gene expression of Maoa, Lyve1, and Ccr2 per cluster. (b) Uniform Manifold Approximation and Projection (UMAP) depicting the gene expression of Slc6a2.(c) Uniform Manifold Approximation and Projection (UMAP) (left) and violin plot (right) showing enrichment of nerve-associated macrophage (NAM) genes and gene set enrichment score (GSES) per cell. The NAM gene set (LEVEAU_NERVE_ASSOCIAED_MACROPHAGES, Table S3) was constructed from bulk RNA sequencing and microarray datasets of NAM-enriched populations in different tissues (adipose tissue, lung, gut, skin, and peripheral nerves); a gene was considered NAM-enriched and included in the NAM gene set if it appeared in 5 or more of the published datasets assessed.(d) Uniform Manifold Approximation and Projection (UMAP) depicting the gene expression of Timd4, Lyve1, and Folr2.

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