Nicotinamide adenine dinucleotide (NAD+) decline is a molecular characteristic of aging and age-associated neurodegenerative diseases. Lee and colleagues uncover an astrocyte-specific regulatory axis directed by the circadian clock component REV-ERBα, and provide proof-of-concept evidence that targeting this pathway alleviates tauopathy in mouse models.
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References
Xie, N. et al. Signal Transduct. Target. Ther. 5, 227 (2020).
Li, C. & Wu, L. E. Mech. Ageing Dev. 198, 111545 (2021).
Lee, J. et al. Nat. Aging https://doi.org/10.1038/s43587-025-00950-x (2025).
Takahashi, J. S. Nat. Rev. Genet. 18, 164–179 (2017).
Asher, G. & Schibler, U. Cell Metab. 13, 125–137 (2011).
Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M. & Sassone-Corsi, P. Science 324, 654–657 (2009).
Dierickx, P. et al. Nat. Cardiovasc. Res. 1, 45–58 (2022).
Lee, J. et al. Aging Cell 19, e13078 (2020).
Lee, J. et al. Nat. Commun. 14, 5197 (2023).
Kojetin, D. J. & Burris, T. P. Nat. Rev. Drug Discov. 13, 197–216 (2014).
Chen, Z., Yoo, S. H. & Takahashi, J. S. Annu. Rev. Pharmacol. Toxicol. 58, 231–252 (2018).
Kim, E., Yoo, S. H. & Chen, Z. F1000Res. 11, 1236 (2022).
Zhang, Y. et al. J. Neurosci. 34, 11929–11947 (2014).
Zhang, R., Lahens, N. F., Ballance, H. I., Hughes, M. E. & Hogenesch, J. B. Proc. Natl Acad. Sci. USA 111, 16219–16224 (2014).
Holth, J. K. et al. Science 363, 880–884 (2019).
Acknowledgements
Research in the Z.C. and S.-H.Y. laboratories is in part supported by the National Institute on Aging (NIA, R01AG089967 and R01AG065984 to Z.C.) and the National Institute of Neurological Disorders and Stroke (NINDS, R01NS136677 to S.-H.Y.).
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Z.C. and S.-H.Y. jointly conceptualized the outline. Z.C. drafted the initial text. S.-H.Y. provided key conceptual input and drafted the figure. Z.C. and S.-H.Y. revised the complete draft and approved the submission.
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Chen, Z., Yoo, SH. Boosting astrocytic NAD+ against tauopathy. Nat Aging 5, 1939–1941 (2025). https://doi.org/10.1038/s43587-025-00979-y
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DOI: https://doi.org/10.1038/s43587-025-00979-y
