Extended Data Fig. 1: Additional age-related functional gene set enrichments in TNBC and ER+ breast cancer (related to Fig. 1).
From: Cell populations in human breast cancers are molecularly and biologically distinct with age
a, b, Differentially expressed genes that were identified as common between TNBC (METABRIC) and basal (TCGA) tumors (a) and ER+ (METABRIC) and Luminal A (TCGA) tumors (b). Red text indicates common enrichment in the >65 age group, blue text indicates enrichment in the <45 age group. Statistical significance was determined using an empirical Bayes-moderated two-sided t test. c, d, GSEA dot plots show pathways that were significantly enriched in <45 (blue) or > 65 (red) age cohorts in TNBC/Basal (a) and ER + /Luminal A breast cancer (b) from METABRIC/TCGA.). Statistical significance and normalized enrichment is determined using a permutation-based null distribution, per the calculations of the fgsea R package. Dot size is proportional to the -log10Benjamini-Hochberg-adjusted p-value; color intensity represents magnitude of normalized enrichment score (NES), according to indicated scales. Pathways were manually grouped by functional similarity.
