Extended Data Fig. 5: Genetic determinants of brain aging clock with functional mapping and annotation. | Nature Aging

Extended Data Fig. 5: Genetic determinants of brain aging clock with functional mapping and annotation.

From: Organ-specific proteomic aging clocks predict disease and longevity across diverse populations

Extended Data Fig. 5: Genetic determinants of brain aging clock with functional mapping and annotation.The alternative text for this image may have been generated using AI.

a, Manhattan and QQ plots of GWAS on brain aging clock. Independent genome-wide significant SNPs were shown in Supplementary Table 15. b, Manhattan and QQ plots of MAGMA gene-based analysis from GWAS on brain aging clock. Input SNPs were mapped to 19839 protein coding genes. Significant genes are shown (P < 0.05/19839). c, MAGMA tissue enrichment analysis of brain ageing clock-related genes in 30 general tissue types from GTEx v8. d, Enrichment test of prioritized genes in differentially expressed gene (DEG) sets from GTEx v8 30 general tissue types. DEG at both sides are shown. No significant tissue enrichment was observed. e, Overlap and enrichment of input genes in GWAS catalog reported gene set (Supplementary Table 16).

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