Extended Data Fig. 1: Aging phenotypes of monkey prostate.
From: Reprogramming the GRHL2−CDK19 axis by gene therapy alleviates prostate aging
a, Representative H&E staining images of the prostate TZ in each monkey. b, H&E staining of the prostate CZ (left) and PZ (right) in young and aged monkeys. c, Masson’s Trichrome staining of the prostate CZ (left) and PZ (right) in young and aged monkeys. d, Immunostaining of αSMA in the prostate CZ (left) and PZ (right) from young and aged monkeys. e, Immunostaining of Ki67 in the prostate TZ in each monkey. b-e, Quantitative data are shown as the mean ± s.e.m. Young, n = 5 monkeys; Aged, n = 5 monkeys. Two-tailed Student’s t-test (b, c, d (fold change in αSMA-positive area of PZ), e), two-tailed Welch’s t-test (d (fold change in αSMA-positive area of CZ)) P values are indicated. Scale bars, 200 μm and 100 μm (b), 500 μm and 200 μm (Zoomed in images) (c), 20 μm (d, e). Y, Young; A, Aged.
