Extended Data Fig. 10: A working model: Allosteric activation of a cell-type specific GPR120 rescues cognition and extends lifespan of Alzheimer’s disease. | Nature Aging

Extended Data Fig. 10: A working model: Allosteric activation of a cell-type specific GPR120 rescues cognition and extends lifespan of Alzheimer’s disease.

From: Allosteric activation of a cell-type-specific GPR120 inhibits amyloid pathology of Alzheimer’s disease

Extended Data Fig. 10: A working model: Allosteric activation of a cell-type specific GPR120 rescues cognition and extends lifespan of Alzheimer’s disease.

a, EDA binds to GPR120 and causes conformational change, enhancing ALA binding affinity to GPR120. b, ALA and EDA allosterically modulate and synergistically activate a cell-type specific GPR120 and GPR120-Gαi1 signaling pathway. c, Allosteric activation of a cell-type specific GPR120-Gαi1-mTORC1 in plaque-associated macrophages and activated microglial cells (PAMAs) rescues cognition and extends lifespan in Alzheimer’s disease mice.

Back to article page