Extended Data Fig. 3: Functional analysis of DC subsets. | Nature Aging

Extended Data Fig. 3: Functional analysis of DC subsets.

From: Attenuating age-related decline in dendritic cell migration improves vaccine efficacy via gut-immune crosstalk

Extended Data Fig. 3: Functional analysis of DC subsets.The alternative text for this image may have been generated using AI.

a, Representative gene expression associated with endocytosis in different DC subsets. b, Representative gene expression associated with antigen processing and presentation in different DC subsets. c, Representative gene expression associated with chemokine signaling pathway in different DC subsets. d, KEGG enrichment analysis of upregulated genes in mig cDC2. e, f, KEGG enrichment analysis of downregulated and upregulated genes in res cDC2. g-i, Representative genes for each pathway of mig cDC2 and res cDC2 in young and aged mice. j, KEGG enrichment analysis of mig cDC2 and res cDC2 in young mice. k, KEGG enrichment analysis of mig cDC2 and res cDC2 in aged mice. Statistical tests: KEGG enrichment analysis was performed using the two-tailed hypergeometric test, with false discovery rate (FDR) correction for multiple comparisons. Adjusted P < 0.05 was considered statistically significant.

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