Extended Data Fig. 6: Selective APOE4 removal from astrocytes has no effect on the morpho-electric and excitability phenotypes of CA3 PCs in young fE4-KIGFAP-Cre+ mice. | Nature Aging

Extended Data Fig. 6: Selective APOE4 removal from astrocytes has no effect on the morpho-electric and excitability phenotypes of CA3 PCs in young fE4-KIGFAP-Cre+ mice.

From: Neuronal APOE4-induced early hippocampal network hyperexcitability in Alzheimer’s disease pathogenesis

Extended Data Fig. 6: Selective APOE4 removal from astrocytes has no effect on the morpho-electric and excitability phenotypes of CA3 PCs in young fE4-KIGFAP-Cre+ mice.

a, Input current - firing rate relationship (I-F Curves). b, Output gain values. c, Rheobase values. d, Spike Latency values. e, Cm values. f, Rin values. All data are represented as mean ± s.e.m. All panels: E3-KI: eight mice, n = 19 cells. fE4-KIGFAP-Cre+: three mice, n = 15 cells. fE4-KIGFAP-Cre-: three mice, n = 19 cells. Significance was assessed using one-way ANOVA with Tukey’s post hoc multiple comparisons test.

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