Extended Data Fig. 10: Lack of Mdga2 CRISPRi effects on neuronal morpho-electric and excitability parameters in young E4-KI mice. | Nature Aging

Extended Data Fig. 10: Lack of Mdga2 CRISPRi effects on neuronal morpho-electric and excitability parameters in young E4-KI mice.

From: Neuronal APOE4-induced early hippocampal network hyperexcitability in Alzheimer’s disease pathogenesis

Extended Data Fig. 10: Lack of Mdga2 CRISPRi effects on neuronal morpho-electric and excitability parameters in young E4-KI mice.

Mdga2 CRISPRi/mCherry+ DGCs display unaltered morpho-electric and excitability parameters: Cm (a), Rin (b), I-F Curves (c), output gain (d), rheobase (e), and spike latency (f). Control (‘cnt’) denotes the mean parameter value of mCherry− cells within each mouse; values were normalized to this mean and expressed as % cnt. All data are represented as mean ± s.e.m. For all panels: four E4-KI mice, n = 14 mCherry+ and 14 mCherry- cells. Statistical significance determined using unpaired two-tailed t-test or Mann-Whitney U test.

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