Extended Data Fig. 9: Identification of adipocytes, vasculature, and lymphatic tissue.

a, Schematic of adipocyte identification. b, Representative example images of adipocytes from young and old patients. Representative images are shown from patients selected from the cohort; similar adipocyte morphology and segmentation performance were observed across all patients included in the analysis. c, Schematic of vascular and lymphatic structure identification; representative examples are shown from patients selected from the cohort, with consistent segmentation performance observed across all analysed images. d, Boxplots depicting shortest distances from individual microenvironment phenotype cells to adipose, vascular, or lymphatic tissue masks. Each data point represents a single cell (technical measurement) pooled across all images and patients. Right-sided bar charts indicate total numbers of cells included per phenotype-structure pair. These analyses are descriptive only and were not used for statistical inference. Boxes show 25th, 50th, and 75th centiles; whiskers indicate 25th/75th centiles ± 1.5 × interquartile range. All scale bars, 150 µm. RF, random forest.