Extended Data Fig. 9: Plots for Anti-inflammatory Drug Target MR using cis-pQTL Data. | Nature Aging

Extended Data Fig. 9: Plots for Anti-inflammatory Drug Target MR using cis-pQTL Data.

From: Repurposing drugs for the prevention of vascular dementia using evidence from drug target Mendelian randomization

Extended Data Fig. 9: Plots for Anti-inflammatory Drug Target MR using cis-pQTL Data.The alternative text for this image may have been generated using AI.

Inverse variance-weighted MR (Mendelian randomization) was conducted for anti-inflammator drug target Mendelian randomization using cis-acting pQTLs (n = 35559) as the exposure with five vascular dementia outcomes; WMH (white matter hyperintensities, n = 50559), iFA (inversed fractional anisotropy, n = 31125), MD (mean diffusivity, n = 31147), LS (lacunar stroke, n = 6030/248929 cases/controls), VaD (vascular dementia diagnosis, n = 7008/899672 cases/controls).). Rheumatoid arthritis (Rh. arthritis) was used as a positive control and is indicated in red (n = 22350/74823 cases/controls). Data are presented as the causal MR estimate as the centre and error bars indicating a +/- a 95% confidence interval (CI), with the minima corresponding to the lower 95% CI bound and the maxima representing the upper 95% CI bound. The number of instrumental variables (IVs) used in each analysis is given, for targets with multiple IVs inverse-variance weighted MR was used, for those with a single IV the Wald ratio was calculated. The F-statistic (Fstat) is also provided as a measure of instrument strength. Pval denotes uncorrected p-values; multiple-comparison corrected p-values (applied at differing levels) are available in the supplement. SD (standard deviation), pQTL (protein quantitative trait loci).

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