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Biological sex shapes divergent trajectories of immune aging

Nature Aging volume 6, pages 750–751 (2026) Cite this article

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Single-cell profiling of nearly 1,000 individuals reveals that immune aging follows distinct cellular and transcriptional trajectories in female and male adults, with stronger cellular and molecular remodeling in female than male participants.

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Fig. 1: Immune remodeling with age is more extensive in female participants.
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References

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This is a summary of: Sopena-Rios, M. et al. Single-cell analysis of the human immune system reveals sex-specific dynamics of immunosenescence. Nat. Aging https://doi.org/10.1038/s43587-026-01099-x (2026).

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Biological sex shapes divergent trajectories of immune aging. Nat Aging 6, 750–751 (2026). https://doi.org/10.1038/s43587-026-01110-5

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