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Cellular and spatial remodeling of aging breast tissue revealed

Nature Aging volume 6, pages 748–749 (2026) Cite this article

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In this study, imaging mass cytometry was used to chart the multicellular dynamics of breast tissue with age. The spatial distribution of 40 proteins in normal tissues from 527 women shows that the density of cells and their proliferation diminish as the breast ages, and that the proportion of inflammatory immune cells increases.

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Fig. 1: Age-associated changes in multicellular neighborhoods of the normal breast.
The alternative text for this image may have been generated using AI.

References

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This is a summary of: Gupta, P. et al. Single-cell spatial atlas of the aging human breast. Nat. Aging https://doi.org/10.1038/s43587-026-01104-3 (2026).

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Cellular and spatial remodeling of aging breast tissue revealed. Nat Aging 6, 748–749 (2026). https://doi.org/10.1038/s43587-026-01111-4

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