Extended Data Fig. 1: Design and mechanism of ALBANC (albumin-linked Au nanocluster) nanoprobes for in vivo detection of chemotherapy-induced senescence and pulmonary fibrosis. | Nature Aging

Extended Data Fig. 1: Design and mechanism of ALBANC (albumin-linked Au nanocluster) nanoprobes for in vivo detection of chemotherapy-induced senescence and pulmonary fibrosis.

From: Urinary detection of therapy-induced senescence and fibrosis using an injectable albumin-based nanoprobe

Extended Data Fig. 1: Design and mechanism of ALBANC (albumin-linked Au nanocluster) nanoprobes for in vivo detection of chemotherapy-induced senescence and pulmonary fibrosis.The alternative text for this image may have been generated using AI.

ALBANC consists of human serum albumin, as a protein carrier, linked to gold nanoclusters (AuNC), as the urinary reporters, via MMP-7-cleavable peptides. After in vivo administration, cleavage of nanoprobes by MMP-7, secreted from therapy-induced senescent cells in lung tumor, or in the case of pulmonary fibrosis, from fibrotic tissues, releases AuNC that undergoes glomerular excretion through the kidneys and becomes concentrated in the urine. The secreted AuNC can be detected using simple assays, enabling colorimetric and spectroscopic detection of diseases in which MMP-7 level is elevated, including senescence and pulmonary fibrosis. Created in BioRender. Fruk, L. (2026) https://BioRender.com/5gfodlo.

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