Table 1 Demographics of the included population from the NOR-Solidarity study
Parameter | SoC + remdesivir | SoC ± HCQ |
|---|---|---|
n = 42 | n = 76 | |
Demographics | ||
Age (years) – mean (SD) | 59.7 (16.5) | 58.4 (14.6) |
Female, n (%) | 13 (31%) | 20 (26.3%) |
Body Mass Index (BMI, kg/m2) – mean (SD) | 28 (5) | 28 (4) |
Body Mass Index (BMI, kg/m2) – median (IQR) | 27 (25–32) | 28 (25 - 31) |
Symptoms prior to admission (no. of days with symptoms) | 7.5 (6.1) | 7.6 (4) |
P/F-ratio at admittance (kPa) – mean (SD) | 38 (13) | 42 (14) |
P/F-ratio <40 kPa, n (%) | 22 (52.4%) | 31 (40.8%) |
Temperature (°C) – mean (SD) | 37.2 (0.9) | 37.6 (1) |
Respiratory rate (breaths/min) – mean (SD) | 21.9 (5.3) | 22.4 (5.5) |
Admitted to ward, n (%) | 39 (92.9%) | 71 (93.4%) |
Admitted to ICU, n (%) | 3 (7.1%) | 5 (6.6%) |
Comorbidities, n (%) | ||
Chronic cardiac disease, including congenital heart disease | 6 (14.6%) | 14 (18.4%) |
Chronic pulmonary disease | 4 (9.8%) | 3 (3.9%) |
Ever smoking | 16 (39%) | 34 (44.7%) |
Hypertension | 15 (36.6%) | 21 (27.6%) |
Diabetes | 9 (22%) | 12 (15.8%) |
Obese (BMI > 30 kg/m2) | 11 (28.9%) | 17 (26.2%) |
Co-medications, n (%) | ||
Steroids | 1 (2.4%) | 3 (4%) |
Other immunomodulatory drugs | 1 (2.4%) | 1 (1.3%) |
ACE inhibitor | 2 (4.9%) | 4 (5.3%) |
AT-II blockers | 11 (26.8%) | 11 (14.7%) |
Haematology, median (IQR) | ||
Haemoglobin (g/dL) | 13.2 (12.4–14.3) | 13.4 (12.7–14.3) |
WBC (x109/L) | 6 (4.9 - 8.7) | 6.3 (4.8–9) |
Neutrophils (x109/L) | 4.3 (2.7–6.8) | 4.7 (3–6.6) |
Lymphocytes (x109/L) | 1.1 (0.9–1.5) | 1 (0.7–1.4) |
Platelet counts (x10^9/L) | 206 (162–268) | 200.5 (159.2–267.2) |
Inflammatory markers, median (IQR) | ||
CRP (mg/L) | 70 (39.8–139.2) | 82 (38.5–138.8) |
Procalcitonin (µg/L) | 0.13 (0.1–0.2) | 0.12 (0.1–0.3) |
Ferritin (µg/L) | 694.5 (343.2–1262.2) | 613 (317.8–1152.5) |
Other, median (IQR) | ||
LDH (U/L) | 284 (234–400) | 267 (209–365) |
D-dimer (mg/L FEU) | 0.76 (0.47–1.03) | 0.6 (0.41–0.95) |
AST | 49 (34.5–77) | 39 (25.2–57) |
ALT | 41 (22–69.2) | 35.5 (20.8–57.2) |
eGFR (mL/min/1.73 m2) | 90.6 (77.2–106.2) | 89.4 (71–104.5) |
Viral count | ||
Viral count (log10 counts/1000 cells) – mean (SD) | 1.6 (1.6) | 2.3 (1.8) |
Anti-SARS-CoV-2 Antibodies, n (%) | ||
Seroconverted (RBD ≥ 5) | 14 (42.4%) | 23 (42.6%) |
Seroconverted (Capsid ≥ 10) | 11 (33.3%) | 19 (35.2%) |