Table 1 Demographics of the included population from the NOR-Solidarity study

From: The effects of remdesivir on long-term symptoms in patients hospitalised for COVID-19: a pre-specified exploratory analysis

Parameter

SoC + remdesivir

SoC ± HCQ

n = 42

n = 76

Demographics

 Age (years) – mean (SD)

59.7 (16.5)

58.4 (14.6)

 Female, n (%)

13 (31%)

20 (26.3%)

 Body Mass Index (BMI, kg/m2) – mean (SD)

28 (5)

28 (4)

 Body Mass Index (BMI, kg/m2) – median (IQR)

27 (25–32)

28 (25 - 31)

 Symptoms prior to admission (no. of days with symptoms)

7.5 (6.1)

7.6 (4)

 P/F-ratio at admittance (kPa) – mean (SD)

38 (13)

42 (14)

 P/F-ratio <40 kPa, n (%)

22 (52.4%)

31 (40.8%)

 Temperature (°C) – mean (SD)

37.2 (0.9)

37.6 (1)

 Respiratory rate (breaths/min) – mean (SD)

21.9 (5.3)

22.4 (5.5)

 Admitted to ward, n (%)

39 (92.9%)

71 (93.4%)

 Admitted to ICU, n (%)

3 (7.1%)

5 (6.6%)

Comorbidities, n (%)

 Chronic cardiac disease, including congenital heart disease

6 (14.6%)

14 (18.4%)

 Chronic pulmonary disease

4 (9.8%)

3 (3.9%)

 Ever smoking

16 (39%)

34 (44.7%)

 Hypertension

15 (36.6%)

21 (27.6%)

 Diabetes

9 (22%)

12 (15.8%)

 Obese (BMI > 30 kg/m2)

11 (28.9%)

17 (26.2%)

Co-medications, n (%)

 Steroids

1 (2.4%)

3 (4%)

 Other immunomodulatory drugs

1 (2.4%)

1 (1.3%)

 ACE inhibitor

2 (4.9%)

4 (5.3%)

 AT-II blockers

11 (26.8%)

11 (14.7%)

Haematology, median (IQR)

 Haemoglobin (g/dL)

13.2 (12.4–14.3)

13.4 (12.7–14.3)

 WBC (x109/L)

6 (4.9 - 8.7)

6.3 (4.8–9)

 Neutrophils (x109/L)

4.3 (2.7–6.8)

4.7 (3–6.6)

 Lymphocytes (x109/L)

1.1 (0.9–1.5)

1 (0.7–1.4)

 Platelet counts (x10^9/L)

206 (162–268)

200.5 (159.2–267.2)

Inflammatory markers, median (IQR)

 CRP (mg/L)

70 (39.8–139.2)

82 (38.5–138.8)

 Procalcitonin (µg/L)

0.13 (0.1–0.2)

0.12 (0.1–0.3)

 Ferritin (µg/L)

694.5 (343.2–1262.2)

613 (317.8–1152.5)

Other, median (IQR)

 LDH (U/L)

284 (234–400)

267 (209–365)

 D-dimer (mg/L FEU)

0.76 (0.47–1.03)

0.6 (0.41–0.95)

 AST

49 (34.5–77)

39 (25.2–57)

 ALT

41 (22–69.2)

35.5 (20.8–57.2)

 eGFR (mL/min/1.73 m2)

90.6 (77.2–106.2)

89.4 (71–104.5)

Viral count

 Viral count (log10 counts/1000 cells) – mean (SD)

1.6 (1.6)

2.3 (1.8)

Anti-SARS-CoV-2 Antibodies, n (%)

 Seroconverted (RBD ≥ 5)

14 (42.4%)

23 (42.6%)

 Seroconverted (Capsid ≥ 10)

11 (33.3%)

19 (35.2%)

  1. ACT angiotensin-converting enzyme, ALT alanine aminotransferase, AST aspartate aminotransferase, ACE angiotensin converting enzyme, AT angiotensin, CRP C-reactive protein, eGFR estimated glomerulus filtration rate, ICU intensive care unit, LDH lactate dehydrogenase, P/F ratio PO2/FiO2 (kPa), WBC total with blood cell counts