Fig. 2: Impaired local recurrent excitation in MCI and AD. | Communications Medicine

Fig. 2: Impaired local recurrent excitation in MCI and AD.

From: Revealing excitation-inhibition imbalance in Alzheimer’s disease using multiscale neural model inversion of resting-state functional MRI

Fig. 2

Boxplot comparison of recurrent excitation weight between a NC and MCI, b NC and AD, and c MCI and AD for all 46 regions (n = 48 for each independent sample). One star (*) indicates uncorrected significance (p < 0.05), double stars (**) indicate corrected significance by FDR (p < 0.05), and triple stars (***) denote corrected significance by the Bonferroni method (p < 0.05). For the boxplots, the central mark indicates the median, and the bottom and top edges of the box indicate the 25th and 75th percentiles, respectively. The whiskers extend to the most extreme data points not considered outliers, and the outliers are plotted individually using the “o” marker symbol (same for figures below). IPC inferior parietal cortex, rACC rostral anterior cingulate cortex, cACC caudal anterior cingulate cortex, ETC entorhinal cortex, PAL pallidum, ACB nucleus accumbens, PCC posterior cingulate cortex, cMFC caudal middle frontal cortex, HPC hippocampus, AMY amygdala, L left hemisphere, R right hemisphere, DMN default mode network, SAL salience network, EXE executive control network, LIM limbic network.

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