Fig. 1: Study design.
From: Long-term immune responses to SARS-CoV-2 Omicron BA.4/5 mRNA booster in people living with HIV
Schematic representation of the study design showing the time-points at which study participants were sampled (a), as well as the number of participants who were enrolled and the immune parameters that were measured at each specified time-point to explore: b peak and durability of immune responses to the original–BA.4/5 bivalent booster in PLWH either with or without previous SARS-CoV-2 infection; c the possible role of the ancestral spike in the bivalent vaccine in exacerbating immunologic imprinting thus affecting the bivalent booster immunogenicity in PLWH; d possible differences in bivalent booster immunogenicity and durability between PLWH and HIV-negative HCWs. Created in BioRender [Augello, M. (2025), https://BioRender.com/t94l162].
