Fig. 2: T and B cell responses. | Communications Medicine

Fig. 2: T and B cell responses.

From: Effect of heterologous intranasal iNCOVACC® vaccination as a booster to two-dose intramuscular Covid-19 vaccination series: a randomized phase 3 clinical trial

Fig. 2

Scatter plots representing T and B cell responses against Ancestral and Omicron strains analysed by ELISPOT assay. SARS-CoV-2-specific IFNγ secreting T cells were measured upon stimulation of PBMCs with a ancestral Spike, b Omicron Spike, c Ancestral MNS, and d Omicron MNS; Similarly, IgG/IgA-secreting plasmablasts were measured upon stimulation of PBMCs with [(e, g)] ancestral whole-virion inactivated antigen and [(f, h)] Omicron Spike (S1) protein. Statistical analysis was performed in Graph-Pad Prism software. ANOVA (Friedman test with Dunn’s multiple comparisons) was performed to compare the CMI responses at different time points (day 0, 28, 56) within each group Further, all five vaccine groups were compared at individual time points by ANOVA (Kruskal–Wallis test with Dunn’s multiple comparisons). There were no significant differences between time points within each group, as well as among the groups, unless otherwise indicated with asterisk/son dotted line (“---” Kruskal–Wallis test) and solid line (“−” Friedman test). SFU indicates spot-forming units. “n” represents the number of samples analysed per group. Each dot represent single data point; Horizontal line represent mean with bars for 95% CI (confidence intervals).

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