Fig. 7: Peripheral cytokines and SARS-CoV-2-specific humoral immunity. | Communications Medicine

Fig. 7: Peripheral cytokines and SARS-CoV-2-specific humoral immunity.

From: Multi-layered deep immune profiling, SARS-CoV-2 RNAemia and inflammation in unvaccinated COVID-19 individuals with persistent symptoms

Fig. 7: Peripheral cytokines and SARS-CoV-2-specific humoral immunity.The alternative text for this image may have been generated using AI.

a IFN-α peripheral concentration expressed in pg/mL. b IL-6 peripheral concentration expressed in pg/mL; Spearman’s correlation between peripheral cytokines and SARS-CoV-2-specific humoral response at T0 in the overall cohort (c), at T1 in the overall cohort (d), at T0 in EPS- individuals (e), at T1 in EPS- individuals (f), at T0 in EPS+ individuals (g), and T1 in EPS+ individuals (h). Red/blue dots: individual values; red/blue lines connecting median values at T0 and T1; longitudinal analyses (T1 compared to T0): Wilcoxon signed-rank test (P values in red/blue); cross-sectional analyses (at each time point): Mann–Whitney U test (P values in black); EPS− (T0, T1): n = 9, 10; EPS+ (T0, T1): n = 10, 10; heatmap of correlations: number in each cell represent the r value, bold-underlined number in each cell represents statistically significant r value; dotted lines: median of 7 pre-pandemic healthy controls. Statistical significance at p-value < 0.05.

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