Table. 3 Multivariable analysis of mortality in the 71,583 CDR and the 143,166 matched controls of the study during the pre-pandemic and pandemic periods (cause-specific Cox models)
From: Evolving impact of the COVID-19 pandemic in chronic dialysis recipients in France
Model | Variable | CDR | Matched controls | ||||
|---|---|---|---|---|---|---|---|
Deaths observed (n)/person-years (n) | HR [95% CI] | p value | Deaths observed (n)/person-years (n) | HR [95% CI] | p value | ||
Model 4 | Pre-pandemic period | 14,455 / 98,444 | 1 (reference) | 10,898 / 231,672 | 1 (reference) | ||
Pandemic period | 13,932 / 86,465 | 1.08 [1.05–1.10] | <0.01 | 11,387 / 222,760 | 1.05 [1.02–1.08] | <0.01 | |
Model 5 | Pre-pandemic period | 14,021 / 98,444 | 10,898 / 231,672 | ||||
Pandemic period, no history of COVID-19-related hospitalization (vs. pre-pandemic period) | 11,924 / 82,804 | 0.98 [0.95–1.00] | 0.07 | 10,110 / 220,149 | 0.96 [0.93–0.98] | <0.01 | |
Pandemic period, ≥1 COVID-19-related hospitalization (vs. pandemic period, no hospitalization) | 2008 / 3661 | 3.48 [3.32–3.65] | <0.01 | 1277 / 2611 | 7.54 [7.11–8.00] | <0.01 | |
Model 6 | Pre-pandemic period | 14,455 / 98,444 | 1 (reference) | 10,898 / 231,672 | 1 (reference) | ||
1st wave | 1235 / 6837 | 1.19 [1.13 –1.27] | <0.01 | 1036 / 17,386 | 1.22 [1.14–1.30] | <0.01 | |
1st inter-wave | 1391 / 9892 | 0.93 [0.88–0.97] | 0.01 | 1075 / 25,117 | 0.87 [0.82–0.93] | <0.01 | |
2nd wave | 3860 / 21,604 | 1.19 [1.15–1.23] | <0.01 | 3234 / 55,077 | 1.21 [1.15–1.25] | <0.01 | |
2nd inter-wave | 2552 / 17,503 | 0.98 [0.94–1.02] | 0.28 | 1966 / 44,564 | 0.91 [0.87–0.96] | <0.01 | |
3rd wave | 2208 / 13,075 | 1.12 [1.07–1.17] | <0.01 | 1843 / 33,764 | 1.13 [1.07–1.18] | <0.01 | |
3rd inter-wave | 2686 / 17,554 | 1.03 [0.98–1.07] | 0.24 | 2233 / 46,852 | 0.97 [0.93–1.02] | 0.20 |
