Fig. 3: Evolution of labels and diagnoses associated with ACU over time.
From: Diagnostic framework to validate clinical machine learning models locally on temporally stamped data
The smoothed line plot in panel a show the ratio of acute care events (ACU) over therapy initiations between January 2010 and June 2022. The smoothed line plot in panel b shows the time to event from therapy initiation, with the mean-normalized number of events on each day after therapy initiation (index date) on the y-axis. The incidence of emergency department (ED) visits and admissions is highest in the first 50 days following therapy initiations. The bar plot (panel c) shows the share (frequency in percent) of diagnosis groups associated with acute care utilization, plotted separately for the retrospective cohort from 2010–2018 (blue) and the prospective validation cohort from 2019–2022 (red).
