Fig. 1: Alterations of the metabolome, lipidome, and clinical parameters in response to ketoacidosis or insulin therapy. | Communications Medicine

Fig. 1: Alterations of the metabolome, lipidome, and clinical parameters in response to ketoacidosis or insulin therapy.

From: Altered branched chain ketoacids underlie shared metabolic phenotypes in type 1 diabetes and maple syrup urine disease

Fig. 1

A Workflow for the collection of plasma, whole blood, and packed red blood cells from patients for metabolomics and lipidomics analysis. B Heat map of the clinical parameters measured at diagnosis for type 1 diabetes mellitus patients, both with and without ketoacidosis. C Heat map of the clinical parameters collected for patients at initial diagnosis (0 d) with type 1 diabetes mellitus and after 14 days (14 d) of insulin therapy. D Heat map of the combined metabolome and lipidome of patient plasma before and after treatment with insulin. E Heat map of the combined metabolome and lipidome of patient red blood cells before and after treatment with insulin. Within all heat maps, hierarchical clustering was utilized to group metabolites, lipids, or clinical parameters that presented similarly across patients. Significant metabolites (p < 0.05) were marked with *.

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