Table 1 The information on the plasma samples from six patients

Patient No.	Biological Sex (F/M)	Age	BMI	Comorbidities	Symptom	Time Point	Sample ID	Interval days	Date of collection	Clinical Treatment	Cre	eGFR
1	M	20–29	20.9	None	Nausea, Muscle cramp	Diagnosis	46-D1	4	2020/08	Cooling & Fluid therapy	1.54	50.5
1	M	20–29	20.9	None	Nausea, Muscle cramp	Recovery	48-R1	4	2020/08	Cooling & Fluid therapy	0.7	119.6
2	M	30–39	Unknown	None	Muscle cramp, Sweating	Diagnosis	33-D2	7	2020/08	Cooling & Fluid therapy	1.49	46.4
2	M	30–39	Unknown	None	Muscle cramp, Sweating	Recovery	35-R2	7	2020/08	Cooling & Fluid therapy	0.74	99.7
3	M	50–59	Unknown	None	Muscle weakness, Nausea	Diagnosis	42-D3	6	2020/08	Cooling & Fluid therapy	2.9	19.1
3	M	50–59	Unknown	None	Muscle weakness, Nausea	Recovery	44-R3	6	2020/08	Cooling & Fluid therapy	1.22	49.2
4	M	40–49	39.4	None	Headache, Nausea	Diagnosis	12-D4	7	2020/08	Cooling & Fluid therapy	1.5	41.8
4	M	40–49	39.4	None	Headache, Nausea	Recovery	14-R4	7	2020/08	Cooling & Fluid therapy	0.85	77.7
5	M	30–39	Unknown	Asthma,　GERD	Dizziness, Muscle weakness	Diagnosis	50-D5	5	2020/08	Cooling & Fluid therapy	1.02	67.3
5	M	30–39	Unknown	Asthma,　GERD	Dizziness, Muscle weakness	Recovery	52-R5	5	2020/09	Cooling & Fluid therapy	0.94	73.6
6	M	80–89	25.2	Hypertension, Tuberculosis	High body temp, Muscle weakness	Diagnosis	56-D6	6	2020/08	Cooling & Fluid therapy	1.11	48.5
6	M	80–89	25.2	Hypertension, Tuberculosis	High body temp, Muscle weakness	Recovery	58-R6	6	2020/09	Cooling & Fluid therapy	0.91	60.3

Each column header has been bolded for clarity. Patient No.: The ID of the patient, ranging from 1 to 6; Biological Sex (F/M): The biological sex of the patient, either female (F) or male (M); Age: Patient age at the time of diagnosis, presented in 10-year ranges (e.g., 20–29) to ensure anonymity. BMI: Body Mass Index of the patient. Comorbidities: Pre-existing medical conditions reported at diagnosis. Symptom: Major symptoms observed during initial diagnosis. Time Point: The time point of the patient’s status when the sample was collected; Sample ID: The recorded name of the sample, where “D” represents the diagnosis time point and “R” represents the recovery time point; Interval days: The number of days between the sample collection at the diagnosis and recovery time points; Date of collection: The date on which the blood sample was collected from the patient. Clinical Treatment: Medical interventions administered to the patient. Cre: Serum creatinine level, used to evaluate kidney function. eGFR: Estimated glomerular filtration rate, a standard metric for assessing renal function.

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