Fig. 5: Plasma-CSF protein levels correlation using samples from young (n = 52) and older (n = 40) adults.
a Log2 abundances of proteins measured in both young and old samples, excluding low-abundant proteins (log2abundance below 10th percentile of correspondingly plasma/CSF protein abundances data); b Plasma-CSF Pearson correlation coefficient per sample for different groups of proteins: (1) all proteins without missing values, (2) proteins measured in both young and old samples, (3) proteins measured in both young and old samples, excluding low-abundant proteins (i.e., proteins shown in a), (4) low molecular weight (MW below 10th percentile) proteins measured in both young and old samples, excluding low-abundant proteins, (5) brain-specific proteins measured in both young and old samples, excluding low-abundant proteins. DBM/OVS: distance between medians divided by overall visible spread as a measure of effect size. The source data for Fig. 5 is deposited with the ProteomeXchange Consortium under accession number MSV000097888.
