Fig. 6: Weighted gene correlation network analysis (WGCNA) results using cerebrospinal fluid and plasma samples from young (n = 52) and older (n = 40) adults.
a Plasma protein co-expression modules demonstrated in a heatmap with correlation coefficients and adjusted p values for associations between plasma protein modules and clinical traits (age, amyloid-β1–42 to amyloid-β1–40 ratio (Aβ1–42/Aβ1–40), phosphorylated tau181 (p-tau181), total tau, and sex); b Cerebrospinal fluid (CSF) protein co-expression modules demonstrated with a heatmap of correlations between CSF modules and clinical traits, highlighting modules involved in extracellular matrix organization, coagulation, inflammation, and synaptic function, which significantly associate with age and CSF p-tau181 levels. The source data for Fig. 4 is in Supplementary Tables s11, s12. (Created with BioRender.com).
