Fig. 2: Description of the dMRI signal models and study overview. | Communications Medicine

Fig. 2: Description of the dMRI signal models and study overview.

From: Clinically feasible liver tumour cell size measurement through histology-informed in vivo diffusion MRI

Fig. 2

A Top: cartoon illustrating the two families of dMRI models considered in this study, consisting of 1) models with no assumption of which of intra/extra-cellular ADC is higher, and 2) models where the extra-cellular ADC is hypothesised to be higher than the intra-cellular ADC. B Bottom: study overview. We analysed dMRI data from fixed mouse livers and from cancer patients imaged in vivo to derive estimates of intra-cellular fraction and of cell size. In parallel, we processed histological material from the same tissues (whole-liver sections for the preclinical mouse data; biopsies from one of the imaged tumours for the clinical data), and derived the histological counterparts of such dMRI metrics. We compared dMRI and histological cell size and intra-cellular fraction to select the dMRI model featuring the best fidelity to histology. In Fig. 2, pictures from Servier Medical Art have been used. Image(s) provided by Servier Medical Art (https://smart.servier.com), licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/).

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