Fig. 5: Examples of maps from the proposed dMRI model Diff-in in liver tumours of patients scanned at 1.5 T and 3 T in vivo, with co-localised biopsies. | Communications Medicine

Fig. 5: Examples of maps from the proposed dMRI model Diff-in in liver tumours of patients scanned at 1.5 T and 3 T in vivo, with co-localised biopsies.

From: Clinically feasible liver tumour cell size measurement through histology-informed in vivo diffusion MRI

Fig. 5

MRI maps are shown in a biopsied liver tumour in two patients for each MRI scanner, arranged along rows. A Examples of slices from the high-resolution anatomical T2-w image and from a high b-value image, with biopsied tumour outlined. B Maps from the selected model (Diff-in, fitted to high b-value images b > 900 s/mm2). From left to right: intra-cellular signal fraction \({{{{\rm{F}}}}}_{{{{\rm{MRI}}}}}\); volume-weighted mean cell size index \({{{\rm{vC}}}}{S}_{{MRI}}\); cell density per unit volume \({{{\rm{C}}}}{D}_{{MRI}}\). C Histological details from the HE-stained biopsy. For the 1.5 T Siemens scanner (first and second rows from top) we report: patient 6 (primary hepatocellular carcinoma) and patient 3 (liver metastases from ovarian cancer). For the 3 T GE scanner (third and fourth rows from top) we report: patient 24 (primary hepatocellular carcinoma (HCC)) and patient 30 (liver metastases from breast cancer).

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